Analysis of immune subtypes across the epithelial-mesenchymal plasticity spectrum

Epithelial-mesenchymal plasticity plays a critical role in many solid tumor types as mediator of metastatic dissemination and treatment resistance. In addition, there is also growing appreciation that the epithelial/mesenchymal status immune evasion suppression. A deeper understanding immunological features different has been facilitated by availability large gene expression datasets development methods to deconvolute bulk RNA-Seq data. These resources have generated powerful new ways characterizing tumors, including classification subtypes based on differential genes. present work, we combine scoring algorithms quantify epithelial-mesenchymal with subtype analysis understand relationship between epithelial across cancers. We find heterogeneity transition (EMT) both within cancer types, greater EMT-related factors than MET-related factors. specific associated EMT scores checkpoint markers.